Caudie C, Schandelong A, Rapoport F, Vial C
Fédération de biologie, Service d'immunologie, Hôpital neurologique, Lyon.
Ann Biol Clin (Paris). 2004 Sep-Oct;62(5):591-4.
We describe a patient who developed overlapping sensory ataxic form of Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) following Campylobacter jejuni infection. Two cerebrospinal fluid examinations shown albuminocytologic dissociation associated with Campylobacter jejuni infection after tongue pierced. He had high titers of monospecific anti-GD1b IgG antibody. Because of the rarety of this disorder the diagnostic was difficult. There is a close association of IgG anti-ganglioside GD1b antibodies in sensory ataxic GBS. The findings of the present study show that antibody to GD1b ganglioside is one of the immunological factors in the pathogenesis of sensory ataxic form of GBS, a rare specific immuno-clinical variant form of GBS with prominent sensory ataxia.
我们描述了一名空肠弯曲菌感染后出现吉兰-巴雷综合征(GBS)和米勒-费雪综合征(MFS)重叠感觉共济失调形式的患者。两次脑脊液检查显示,在舌穿孔后发生空肠弯曲菌感染,出现蛋白细胞分离。他具有高滴度的单特异性抗GD1b IgG抗体。由于这种疾病罕见,诊断困难。感觉共济失调型GBS中IgG抗神经节苷脂GD1b抗体存在密切关联。本研究结果表明,抗GD1b神经节苷脂抗体是感觉共济失调型GBS发病机制中的免疫因素之一,GBS是一种罕见的具有突出感觉性共济失调的特异性免疫临床变异型。