Maxwell Andrew J
Thoracic Organ Transplant and PPH Program, University of Pennsylvania, Philadelphia, PA, USA.
Nitric Oxide. 2002 Mar;6(2):101-24. doi: 10.1006/niox.2001.0394.
Vascular nitric oxide (NO) is involved in many physiologic and pathophysiologic processes throughout the body. Many vascular diseases have a reduction in the activity of endothelium-derived NO as an important component involved in the initiation and/or progression of the disease. It is now known that there are multiple mechanisms for this reduction in NO activity with one or more mechanisms operating depending on the specific condition or stage of a disease. In other instances, the therapy for certain diseases is responsible for the reduction in NO activity and contributes to the acceleration of vascular disease. This review details the known mechanisms of dysfunction of the NO pathway leading to vascular diseases, which provides the rationale for why certain therapies can improve while other therapies adversely affect vascular health.
血管一氧化氮（NO）参与全身许多生理和病理生理过程。许多血管疾病都存在内皮源性NO活性降低的情况，这是疾病发生和/或发展过程中的一个重要因素。目前已知，NO活性降低存在多种机制，具体取决于疾病的特定情况或阶段，一种或多种机制会起作用。在其他情况下，某些疾病的治疗会导致NO活性降低，并加速血管疾病的发展。这篇综述详细阐述了导致血管疾病的NO信号通路功能障碍的已知机制，这为某些治疗方法为何能改善血管健康而其他治疗方法却会产生不利影响提供了理论依据。
