Kato Yoshinori, Onishi Hiraku, Machida Yoshiharu
Department of Drug Delivery Research, Hoshi University, Tokyo, Japan.
Carbohydr Res. 2002 Mar 15;337(6):561-4. doi: 10.1016/s0008-6215(02)00021-6.
N-Succinyl-chitosan (1) was depolymerized with 7.5 M aqueous HCl at room temperature or 3.3 M aqueous HCl at 40 degrees C and the molecular weights (MW) of the products were determined by size-exclusion chromatography-multi angle light scattering (SEC-MALS) and their viscometric features were investigated. The intrinsic viscosity ([eta]) obtained at the concentration of 0.1-0.3% (w/v) in saline showed a linear relationship between log[eta] and log MW, which provided the coefficients in the Mark-Houwink equation.
N-琥珀酰壳聚糖（1）在室温下用7.5 M盐酸水溶液或在40℃下用3.3 M盐酸水溶液进行解聚，通过尺寸排阻色谱 - 多角度光散射（SEC-MALS）测定产物的分子量（MW），并研究其粘度特性。在生理盐水中0.1 - 0.3%（w/v）浓度下获得的特性粘度（[η]）显示log[η]与log MW之间呈线性关系，这给出了马克 - 豪温克方程中的系数。
