Dixon K L, Agrawal S K B, Chan K M J
Department of Nuclear Medicine, Walsgrave Hospital, UK.
Nucl Med Commun. 2002 Mar;23(3):275-82. doi: 10.1097/00006231-200203000-00012.
Changes in pulmonary permeability provide a partial measure of the clinical impact of biocompatible oxygenator use during cardiopulmonary bypass surgery. Previous research has shown that the clearance rate of 99mTc-labelled diethylene triamine penta-acetic acid (99mTc-DTPA) aerosol from the lungs is increased following cardiopulmonary bypass, resulting from an increase in pulmonary permeability. The aerosol clearance rate has been shown to return to normal after a period of 7 days. A blind trial was set up to assess the clinical impact of a biocompatible, Trillium-coated oxygenator compared with a standard oxygenator. In a group of 25 patients 99mTc-DTPA aerosol studies were carried out prior to cardiopulmonary bypass surgery for mitral valve surgery. Repeat studies were undertaken 3-4 h and 24-28 h after surgery. Analysis of the rates of pulmonary clearance reproduced the trends seen in earlier research. There was however no statistically significant difference in the variation of serial clearance times between the groups of patients undergoing surgery using the Trillium-coated oxygenators and those using the standard oxygenators.
肺通透性的变化部分衡量了体外循环手术中使用生物相容性氧合器对临床的影响。先前的研究表明，体外循环后，肺对99m锝标记的二乙三胺五乙酸（99mTc-DTPA）气溶胶的清除率会升高，这是肺通透性增加所致。气溶胶清除率在7天后会恢复正常。开展了一项盲法试验，以评估一种生物相容性的、涂有延龄草的氧合器与标准氧合器相比对临床的影响。在一组25例因二尖瓣手术而进行体外循环手术的患者中，于术前进行了99mTc-DTPA气溶胶研究。术后3 - 4小时和24 - 28小时进行了重复研究。对肺清除率的分析重现了早期研究中观察到的趋势。然而，在使用涂有延龄草的氧合器进行手术的患者组和使用标准氧合器的患者组之间，连续清除时间的变化没有统计学上的显著差异。
