Abela G S, Hage-Korban E E, Tomaru T, Barbeau G R, Abela O G, Friedl S E
Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, Michigan 48824, USA.
Lasers Surg Med. 2001;29(5):455-63. doi: 10.1002/lsm.10000.
Exposure of the arterial wall matrix to blood leads to platelet deposition resulting in thrombosis. Because heat alters tissue matrix we proposed that heating reduces platelet deposition.
STUDY DESIGN/MATERIALS AND METHODS: Sixty arterial homografts (15 dogs) were mounted in an arterio-venous "shunt." Interventions included balloon angioplasty (BA), direct laser (LA), laser-thermal (LTA), and combined LTABA. 111Indium-labeled platelets were circulated, radio activity measured, and homografts processed for histology.
Radioactivity count (mean+/- SE) at BA sites (13,853+/-3,192 cpm/cm(2)) was greater than LA (7,038+/-981), LTA (5,294 +/-1,145), LTABA (6,176+/-1,571), and control (1,826+/-339), P<0.05. Electron microscopy showed fewer platelets at LA, LTA, and control than BA sites. BA spread the collagen on the arterial lumen while heat gelled collagen and confined it to the arterial media.
Heating the artery and gelling collagen during LA, LTA, or LTABA significantly reduced thrombogenicity.
动脉壁基质暴露于血液会导致血小板沉积，进而引发血栓形成。由于热会改变组织基质，我们提出加热可减少血小板沉积。
研究设计/材料与方法：将60个动脉同种移植物（取自15只犬）植入动静脉“分流管”中。干预措施包括球囊血管成形术（BA）、直接激光治疗（LA）、激光热治疗（LTA）以及联合激光热球囊血管成形术（LTABA）。使111铟标记的血小板循环，测量放射性，并对同种移植物进行组织学处理。
BA部位的放射性计数（均值±标准误）为（13,853±3,192 cpm/cm²），高于LA（7,038±981）、LTA（5,294±1,145）、LTABA（6,176±1,571）以及对照组（1,826±339），P<0.05。电子显微镜显示，LA、LTA及对照组的血小板数量少于BA部位。BA使胶原蛋白在动脉管腔内扩散，而加热则使胶原蛋白凝胶化并将其限制在动脉中层。
在LA、LTA或LTABA过程中加热动脉并使胶原蛋白凝胶化可显著降低血栓形成倾向。
