Ulkür Ersin, Yüksel Fuat, Açikel Cengiz, Celiköz Bahattin
Department of Plastic and Reconstructive Surgery, Gülhane Military Medical Academy and Medical School, Haydarpşa Teaching Hospital, Istanbul, Turkey.
Microsurgery. 2002;22(1):16-20. doi: 10.1002/micr.22004.
The effect of hyperbaric oxygen (HBO) on the survival rate of experimental rat pedicle island flaps with arterial, venous, and combined arteriovenous insufficiency was evaluated. Forty male Wistar rats with pedicle island flaps were divided into four groups with different types of vascular status. Another 40 male Wistar rats, also divided into four groups, were reconstructed in the same manner, but were also exposed to HBO. The results were evaluated using a laser Doppler flowmeter and an estimation of the length of the surviving tissue of the flaps. In evaluations using Kruskal-Wallis test, there was a significant difference in the survival tissue length and mean LD flows among our four untreated groups (P < 0.05). We considered the experimental model defined by Tzusuki and colleagues suitable for our study. Using a Mann-Whitney test, the differences in flap tissue survival length between each type of vascular insufficiency of HBO-treated and untreated groups was significant (P < 0.05). This finding indicates that the survival length was directly improved by the HBO treatment for all type of vascular insufficiency. HBO treatment increased the percentage of survival length and mean LD flows of axial pattern skin flaps with all type of vascular insufficiency. This effect, however, was greatest in the arterial insufficiency flaps.
评估了高压氧（HBO）对伴有动脉、静脉及动静脉联合供血不足的实验大鼠带蒂岛状皮瓣存活率的影响。40只制作了带蒂岛状皮瓣的雄性Wistar大鼠被分为四组，每组具有不同类型的血管状态。另外40只雄性Wistar大鼠也被分为四组，以同样的方式进行构建，但同时接受高压氧治疗。使用激光多普勒血流仪和皮瓣存活组织长度估计来评估结果。在使用Kruskal-Wallis检验的评估中，我们的四个未治疗组在存活组织长度和平均激光多普勒血流方面存在显著差异（P<0.05）。我们认为Tzusuki及其同事定义的实验模型适用于我们的研究。使用Mann-Whitney检验，高压氧治疗组和未治疗组每种血管供血不足类型的皮瓣组织存活长度差异显著（P<0.05）。这一发现表明，对于所有类型的血管供血不足，高压氧治疗可直接改善存活长度。高压氧治疗提高了所有类型血管供血不足的轴型皮瓣的存活长度百分比和平均激光多普勒血流。然而，这种效果在动脉供血不足皮瓣中最为明显。
