Frikha H, Kochbati L, Daoud J, Ben Romdhane K, Maalej M
Service de Radiothérapie, Institut Salah Azaiz, Tunis.
Tunis Med. 2001 Dec;79(12):647-54.
A better knowledge of the radiobiological effects and the control of the techniques of dosimetry led to a renewed interest for the radiotherapy of the benign lesions. The doses used for these indications are weaker than those recommended for treatment of cancer and the radiobiological mechanisms implied are different. The aim of this review of the literature is to specify the radiobiological mechanisms, the risks and the place of ionizing radiations during the processing of the benign lesions. Although the risk of radiation induced neoplasms remains a limiting factor of the indications, those are very varied. Some indications are well accepted such as keloid, cerebral arteriovenous malformations, graves' ophtalmopathy, prevention of postoperative heterotopic bone formations; and some others remain still controversial such as the prevention of the post angioplasty restenosis and age-related macular degeneration.
对放射生物学效应以及剂量测定技术控制的更深入了解,引发了人们对良性病变放射治疗的新兴趣。用于这些适应症的剂量比推荐用于癌症治疗的剂量要低,且其中涉及的放射生物学机制也有所不同。这篇文献综述的目的是明确在良性病变治疗过程中电离辐射的放射生物学机制、风险及地位。尽管辐射诱发肿瘤的风险仍是适应症的一个限制因素,但这些适应症种类繁多。一些适应症已被广泛接受,如瘢痕疙瘩、脑动静脉畸形、格雷夫斯眼病、预防术后异位骨形成;而其他一些仍存在争议,如预防血管成形术后再狭窄和年龄相关性黄斑变性。