Gagliardi M Cristina, Sallusto Federica, Marinaro Mariarosaria, Vendetti Silvia, Riccomi Antonella, De Magistris M Teresa
Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Rome, Italy.
Int J Med Microbiol. 2002 Feb;291(6-7):571-5. doi: 10.1078/1438-4221-00169.
Cholera toxin (CT) is a potent mucosal adjuvant. When administered through the mucosal route CT amplifies B and T lymphocyte responses to co-administered antigens. Since the discovery of CT as a mucosal adjuvant, other bacterial enterotoxins have been found to have this property. These molecules or their detoxified derivatives are all important for the development of mucosal vaccines for human use, and it is thus necessary to understand their mechanism of action. CT has immunomodulatory effects on different cell types, however, the interaction of CT with dendritic cells (DCs), which have a primary role in the priming of immune responses, may be crucial for its adjuvant activity.
霍乱毒素（CT）是一种强效的黏膜佐剂。通过黏膜途径给药时，CT可增强B淋巴细胞和T淋巴细胞对共同给药抗原的反应。自CT作为黏膜佐剂被发现以来，人们还发现其他细菌肠毒素也具有这一特性。这些分子或其解毒衍生物对于开发供人类使用的黏膜疫苗都很重要，因此有必要了解它们的作用机制。CT对不同细胞类型具有免疫调节作用，然而，CT与在免疫反应启动中起主要作用的树突状细胞（DC）之间的相互作用，可能对其佐剂活性至关重要。
