Niu Y G, Zhang L F, Zhang Y H, Wang S Y, Xu X Y, Su J X, Yan Y B
Department of Aerospace Physiology, The Fourth Military Medical University, Xi'an China.
Space Med Med Eng (Beijing). 2001 Jun;14(3):177-81.
Objective. To estimate the cardiovascular age of civil flying personnel by means of heart rate and blood pressure variability analysis and to evaluate its significance in aviation medicine. Method. First, heart rate variability (HRV), blood pressure variability (BPV) and spontaneous baroreflex sensitivity (BRS) were analyzed among 89 healthy civil flying personnel by using conventional AR spectral analysis and sequence method respectively. Then, principal component analysis was conducted over original and derived variables of HRV and BPV spectral and BRS data. Finally, by the use of multiple regression in which the chronological age acted as the dependent variable and the components significantly related to age were used as the regressors, the equation for estimating the cardiovascular age was established. Result. Only seven principal components can exactly reflect the same information of autonomic regulatory function which was embodied in the 17 variables of HRV and BPV spectral and BRS parameters. Among the seven principal components, the PC2orig, PC4orig and PC2deri were negatively correlated with chronological age (P<0.05), whereas the PC3orig was positively correlated with the chronological age (P<0.01). The cardiovascular age derived from the equation was significantly correlated with the chronological age of the civil flying personnel (r= 0.73, P<0.01). Conclusion. The cardiovascular age estimated by means of a multi-variate analysis of HRV, BPV and BRS can be treated as a comprehensive indicator reflecting the age dependency of autonomic regulatory function of cardiovascular system in healthy civil flying personnel, and its interpretation and significance in application are surely worthy of further and fully dedicated efforts.
目的。通过心率和血压变异性分析评估民航飞行人员的心血管年龄，并评价其在航空医学中的意义。方法。首先，分别采用传统AR谱分析和序列法对89名健康民航飞行人员的心率变异性（HRV）、血压变异性（BPV）和自发性压力反射敏感性（BRS）进行分析。然后，对HRV、BPV谱和BRS数据的原始变量及导出变量进行主成分分析。最后，以实际年龄作为因变量，将与年龄显著相关的成分为自变量，采用多元回归建立心血管年龄估计方程。结果。仅7个主成分就能准确反映HRV、BPV谱和BRS参数17个变量所体现的自主调节功能的相同信息。在这7个主成分中，PC2orig、PC4orig和PC2deri与实际年龄呈负相关（P<0.05），而PC3orig与实际年龄呈正相关（P<0.01）。由方程得出的心血管年龄与民航飞行人员的实际年龄显著相关（r=0.73，P<0.01）。结论。通过对HRV、BPV和BRS进行多变量分析估计出的心血管年龄，可作为反映健康民航飞行人员心血管系统自主调节功能年龄依赖性的综合指标，其在应用中的解读和意义确实值得进一步深入研究。
