阿片类药物耐受性——探寻圣杯
Opioid tolerance-in search of the holy grail.
作者信息
Kieffer Brigitte L, Evans Christopher J
机构信息
Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67400 Illkirch, France.
出版信息
Cell. 2002 Mar 8;108(5):587-90. doi: 10.1016/s0092-8674(02)00666-9.
Abstract
Tolerance, one of several behavioral adaptations to prolonged opioid treatment, has long been explained by desensitization of opioid receptor signaling and loss of surface receptors. However, recent evidence presents an alternative hypothesis, suggesting that receptor internalization could in fact reduce tolerance in vivo.
摘要
耐受性是对长期阿片类药物治疗的几种行为适应性之一，长期以来一直被解释为阿片受体信号脱敏和表面受体丧失。然而，最近的证据提出了另一种假说，表明受体内化实际上可能会降低体内的耐受性。
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