Peier Andrea M, Moqrich Aziz, Hergarden Anne C, Reeve Alison J, Andersson David A, Story Gina M, Earley Taryn J, Dragoni Ilaria, McIntyre Peter, Bevan Stuart, Patapoutian Ardem
Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
Cell. 2002 Mar 8;108(5):705-15. doi: 10.1016/s0092-8674(02)00652-9.
A distinct subset of sensory neurons are thought to directly sense changes in thermal energy through their termini in the skin. Very little is known about the molecules that mediate thermoreception by these neurons. Vanilloid Receptor 1 (VR1), a member of the TRP family of channels, is activated by noxious heat. Here we describe the cloning and characterization of TRPM8, a distant relative of VR1. TRPM8 is specifically expressed in a subset of pain- and temperature-sensing neurons. Cells overexpressing the TRPM8 channel can be activated by cold temperatures and by a cooling agent, menthol. Our identification of a cold-sensing TRP channel in a distinct subpopulation of sensory neurons implicates an expanded role for this family of ion channels in somatic sensory detection.
一种独特的感觉神经元亚群被认为可通过其在皮肤中的末梢直接感知热能变化。对于介导这些神经元热感受的分子，人们了解甚少。香草酸受体1（VR1）是瞬时受体电位（TRP）通道家族的成员，可被有害热激活。在此，我们描述了TRPM8的克隆与特性，它是VR1的远亲。TRPM8在一部分痛觉和温度感受神经元中特异性表达。过表达TRPM8通道的细胞可被低温和一种冷却剂薄荷醇激活。我们在感觉神经元的一个独特亚群中鉴定出一种冷感受TRP通道，这意味着该离子通道家族在躯体感觉检测中发挥着更广泛的作用。
