Giannaccari Marialaura, Florindi Chiara, Bloise Nora, Moccia Francesco, Lodola Francesco, Visai Livia
Molecular Medicine Department (DMM), Centre for Health Technologies (CHT), Unità Di Ricerca (UdR) INSTM, Operative Unit (OU) of the Interuniversity Center for the Promotion of the 3Rs Principles in Teaching and Research (Centro 3R), University of Pavia, Pavia, 27100, Italy.
Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, 20126, Italy.
J Exp Clin Cancer Res. 2025 Aug 14;44(1):240. doi: 10.1186/s13046-025-03495-4.
Transient receptor potential (TRP) channels are a large family of non-selective cation channels that play critical roles in cellular homeostasis and signal transduction. Recent investigations have clearly highlighted their involvement in cancer biology, particularly in the regulation of cancer metabolism. Unlike normal cells, cancer cells tend to favour the energy inefficient glycolytic pathway over the more effective oxidative phosphorylation process. TRP channels are involved in critical steps of cancer-related metabolic reprogramming by influencing intracellular Ca signaling. Their dysregulation can intensify oxidative stress, thereby promoting oncogenic transformation and tumor progression. The intricate interplay between TRP channels, metabolic reprogramming and oxidative stress promotes cancer cell progression and resistance to treatment. This review highlights the crucial role of TRP channels in tumorigenesis. It examines how TRPM7 and TRPM8 contribute to metabolic reprogramming by its involvement in glycolysis pathway. Additionally, it explores the involvement of TRPML1, TRPA1, TRPM2, and TRPV1 in modulating reactive oxygen species (ROS) levels within cancer cells, analyzing the ROS dual role in tumor modulation. The advent of nanotechnology, particularly through the utilisation of engineered nanoparticles, has facilitated the selective modulation of TRPA1, TRPM2, and TRPV1 channels. This technological breakthrough has paved the way for novel and more targeted anticancer treatment strategies. The integration of molecular insights with cutting-edge technological approaches holds great promise for the development of more effective and targeted cancer treatments.
瞬时受体电位（TRP）通道是一类大家族的非选择性阳离子通道，在细胞内稳态和信号转导中发挥关键作用。最近的研究清楚地突出了它们在癌症生物学中的参与，特别是在癌症代谢的调节方面。与正常细胞不同，癌细胞倾向于偏好能量效率低下的糖酵解途径，而非更有效的氧化磷酸化过程。TRP通道通过影响细胞内钙信号传导参与癌症相关代谢重编程的关键步骤。它们的失调会加剧氧化应激，从而促进致癌转化和肿瘤进展。TRP通道、代谢重编程和氧化应激之间复杂的相互作用促进了癌细胞的进展和对治疗的抗性。本综述突出了TRP通道在肿瘤发生中的关键作用。它研究了TRPM7和TRPM8如何通过参与糖酵解途径促进代谢重编程。此外，它探讨了TRPML1、TRPA1、TRPM2和TRPV1在调节癌细胞内活性氧（ROS）水平中的参与，分析了ROS在肿瘤调节中的双重作用。纳米技术的出现，特别是通过利用工程化纳米颗粒，促进了对TRPA1、TRPM2和TRPV1通道的选择性调节。这一技术突破为新颖且更具靶向性的抗癌治疗策略铺平了道路。将分子见解与前沿技术方法相结合，对于开发更有效且具靶向性的癌症治疗方法具有巨大的前景。
