Sato Katsuro, Kawana Masahiro, Sato Yuichiro, Takahashi Sugata
Department of Otolaryngology, Niigata University School of Medicine, 1-757 Asahimachi, 951-8510, Niigata, Japan.
Auris Nasus Larynx. 2002 Apr;29(2):209-14. doi: 10.1016/s0385-8146(01)00144-4.
Lymphoepithelial lesion is a benign lymphoproliferative disease occasionally arises in the salivary glands, but association with malignant diseases or autoimmune diseases has also been discussed. We herein present three cases of malignant lymphoma arose in the parotid gland and the lacrimal gland, following parotid surgery for benign lymphoepithelial lesion (BLEL) of the parotid gland. Two cases had mucosa associated lymphoid tissue (MALT) lymphoma in the parotid gland; one arose in the ipsilateral parotid gland as a recurrent swelling, and the other arose in the contralateral parotid gland of the previous BLEL surgery. The third case of malignant lymphoma arose in the lacrimal gland on the ipsilateral side, and the following contralateral parotid gland remained BLEL. All three patients were female, and one patient had a past history of Sjögren's syndrome and Hashimoto's disease. All three patients were treated by chemotherapy and one patient received additional radiotherapy. To follow-up lymphoproliferative diseases in the salivary glands such as BLEL, careful observation should be made on the same gland, other major salivary glands, and other organs in the head and neck, especially in females with autoimmune diseases.
淋巴上皮病变是一种良性淋巴增生性疾病，偶尔发生于唾液腺，但也有人探讨过它与恶性疾病或自身免疫性疾病的关联。我们在此报告3例腮腺和泪腺发生的恶性淋巴瘤病例，这些病例均发生于腮腺良性淋巴上皮病变（BLEL）行腮腺手术后。2例腮腺发生黏膜相关淋巴组织（MALT）淋巴瘤；1例在同侧腮腺以复发性肿胀出现，另1例在先前BLEL手术对侧的腮腺发生。第3例恶性淋巴瘤发生于同侧泪腺，而对侧腮腺仍为BLEL。所有3例患者均为女性，1例患者有干燥综合征和桥本氏病病史。所有3例患者均接受化疗，1例患者还接受了放疗。为了随访唾液腺的淋巴增生性疾病如BLEL，应对同一腺体、其他主要唾液腺以及头颈部其他器官进行仔细观察，尤其是患有自身免疫性疾病的女性。
