染色质中开关状态的编程：多梳蛋白和三胸节复合物的机制

Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes.

作者信息

Simon Jeffrey A, Tamkun John W

机构信息

Department of Genetics, Cell Biology and Development, University of Minnesota, 321 Church St., Minneapolis, Minnesota 55455, USA.

出版信息

Curr Opin Genet Dev. 2002 Apr;12(2):210-8. doi: 10.1016/s0959-437x(02)00288-5.

DOI:10.1016/s0959-437x(02)00288-5

PMID:11893495

Abstract

Polycomb and trithorax group proteins are evolutionarily conserved chromatin components that maintain stable states of gene expression. Recent studies have identified and characterized several multiprotein complexes containing these transcriptional regulators. Advances in understanding molecular activities of these complexes in vitro, and functional domains present in their subunits, suggest that they control transcription through multistep mechanisms that involve nucleosome modification, chromatin remodeling, and interaction with general transcription factors.

摘要

多梳蛋白和三胸节蛋白家族是进化上保守的染色质组分，它们维持基因表达的稳定状态。最近的研究已经鉴定并表征了几种含有这些转录调节因子的多蛋白复合物。在体外理解这些复合物的分子活性以及其亚基中存在的功能结构域方面取得的进展表明，它们通过涉及核小体修饰、染色质重塑以及与通用转录因子相互作用的多步骤机制来控制转录。