Voderholzer Ulrich, Weske Gesa, Ecker Sabine, Riemann Dieter, Gann Horst, Berger Mathias
Department of Psychiatry and Psychotherapy, Albert Ludwig University, Freiburg, Germany.
Neuropsychobiology. 2002;45 Suppl 1:13-9. doi: 10.1159/000049256.
48-hour rapid cycling is a very rare form of bipolar disorder, characterized by regular periodic changes of mood from one day to the other. We report on a patient who suffered from a 48-hour rapid cycling without a history of bipolar disorder before the abrupt onset of his rapid mood cycles. We present polysomnographic and neuroendocrine findings and the clinical course based on daily self-ratings of mood. Treatment with lithium carbonate effectively reduced the amplitude of the mood cycles. With plasma levels between 0.8 and 1.0 mmol, almost complete remission occurred. An overview on previous reports on the therapeutic effect of mood stabilizers in this rare form of bipolar disorder is presented.
48小时快速循环是双相情感障碍一种非常罕见的形式，其特征是情绪在一天到另一天之间有规律地周期性变化。我们报告了一名患者，他在快速情绪循环突然发作之前没有双相情感障碍病史，却患上了48小时快速循环型双相情感障碍。我们展示了多导睡眠图和神经内分泌检查结果以及基于每日情绪自评的临床病程。碳酸锂治疗有效降低了情绪循环的幅度。当血浆水平在0.8至1.0毫摩尔之间时，几乎实现了完全缓解。本文还概述了此前关于心境稳定剂对这种罕见形式双相情感障碍治疗效果的报道。
