雌激素和/或孕酮对去卵巢大鼠离体子宫的影响。对血管紧张素II的反应性。

Influence of estrogen and/or progesterone on isolated ovariectomized rat uterus. Responsiveness to Ang II.

作者信息

Accorsi-Mendonça D, Corrêa F M A, Anselmo-Franci J A, de Oliveira A M

机构信息

Department of Pharmacology, Medicine College of Ribeirão Preto, USP, Brazil.

出版信息

Pharmacology. 2002 Apr;64(4):208-13. doi: 10.1159/000056173.

DOI:10.1159/000056173

PMID:11893902

Abstract

Steroids hormones can influence several functions of the uterus, including agonist-induced contractions. The aim of this work is to study the influence of hormonal replacement on angiotensin II (Ang II) and losartan responsiveness on the isolated rat uterus. The Ang II pD(2) values are: 9.69 +/- 0.07 for vehicle-treated animals, 8.85 +/- 0.06 for estrogen-treated animals, 10.12 +/- 0.03 for progesterone-treated animals and 8.90 +/- 0.03 for estrogen-and-progesterone-treated animals. The losartan pD(2)' values are: 8.43 +/- 0.03 for vehicle-treated animals, 8.21 +/- 0.03 for estrogen-treated animals, 7.83 +/- 0.05 for progesterone-treated animals and 8.70 +/- 0.09 for estrogen-and-progesterone-treated animals. There is not a correlation between Ang II pD(2) and losartan pD(2)' values, suggesting that the hormones affect Ang II and losartan binding by different mechanisms in rat uterus.

摘要

甾体激素可影响子宫的多种功能，包括激动剂诱导的收缩。本研究的目的是探讨激素替代对离体大鼠子宫中血管紧张素II（Ang II）和氯沙坦反应性的影响。Ang II的pD(2)值分别为：溶剂处理组动物为9.69±0.07，雌激素处理组动物为8.85±0.06，孕激素处理组动物为10.12±0.03，雌激素和孕激素联合处理组动物为8.90±0.03。氯沙坦的pD(2)'值分别为：溶剂处理组动物为8.43±0.03，雌激素处理组动物为8.21±0.03，孕激素处理组动物为7.83±0.05，雌激素和孕激素联合处理组动物为8.70±0.09。Ang II的pD(2)值与氯沙坦的pD(2)'值之间无相关性，提示激素通过不同机制影响大鼠子宫中Ang II和氯沙坦的结合。