运动信号的即时神经控制。

Instant neural control of a movement signal.

作者信息

Serruya Mijail D, Hatsopoulos Nicholas G, Paninski Liam, Fellows Matthew R, Donoghue John P

机构信息

Department of Neuroscience, Box 1953, Brown University, Providence, Rhode Island 02912, USA.

出版信息

Nature. 2002 Mar 14;416(6877):141-2. doi: 10.1038/416141a.

DOI:10.1038/416141a

PMID:11894084

Abstract

The activity of motor cortex (MI) neurons conveys movement intent sufficiently well to be used as a control signal to operate artificial devices, but until now this has called for extensive training or has been confined to a limited movement repertoire. Here we show how activity from a few (7-30) MI neurons can be decoded into a signal that a monkey is able to use immediately to move a computer cursor to any new position in its workspace (14 degrees x 14 degrees visual angle). Our results, which are based on recordings made by an electrode array that is suitable for human use, indicate that neurally based control of movement may eventually be feasible in paralysed humans.

摘要

运动皮层（MI）神经元的活动能够充分传递运动意图，足以用作操作人工装置的控制信号，但迄今为止，这需要进行大量训练，或者局限于有限的运动指令集。在此，我们展示了如何将少数（7 - 30个）MI神经元的活动解码为一种信号，猴子能够立即利用该信号将计算机光标移动到其工作空间（14度×14度视角）内的任何新位置。我们的结果基于适合人类使用的电极阵列所做的记录，表明基于神经的运动控制最终在瘫痪的人类中可能是可行的。