Singer-Clark Tyler, Hou Xianda, Card Nicholas S, Wairagkar Maitreyee, Iacobacci Carrina, Peracha Hamza, Hochberg Leigh R, Stavisky Sergey D, Brandman David M
Department of Neurological Surgery, University of California Davis, Davis, CA, United States of America.
Biomedical Engineering Graduate Group, University of California Davis, Davis, CA, United States of America.
J Neural Eng. 2025 May 14;22(3). doi: 10.1088/1741-2552/add0e5.
Decoding neural activity from ventral (speech) motor cortex is known to enable high-performance speech brain-computer interface (BCI) control. It was previously unknown whether this brain area could also enable computer control via neural cursor and click, as is typically associated with dorsal (arm and hand) motor cortex.We recruited a clinical trial participant with amyotrophic lateral sclerosis and implanted intracortical microelectrode arrays in ventral precentral gyrus (vPCG), which the participant used to operate a speech BCI in a prior study. We developed a cursor BCI driven by the participant's vPCG neural activity, and evaluated performance on a series of target selection tasks.The reported vPCG cursor BCI enabled rapidly-calibrating (40 s), accurate (2.90 bits per second) cursor control and click. The participant also used the BCI to control his own personal computer independently.These results suggest that placing electrodes in vPCG to optimize for speech decoding may also be a viable strategy for building a multi-modal BCI which enables both speech-based communication and computer control via cursor and click. (BrainGate2 ClinicalTrials.gov ID NCT00912041).
已知从腹侧（言语）运动皮层解码神经活动能够实现高性能的言语脑机接口（BCI）控制。此前尚不清楚该脑区是否也能像通常与背侧（手臂和手部）运动皮层相关联的那样，通过神经光标和点击实现计算机控制。我们招募了一名肌萎缩侧索硬化症的临床试验参与者，并在其腹侧中央前回（vPCG）植入了皮层内微电极阵列，该参与者在之前的一项研究中曾使用该阵列来操作言语BCI。我们开发了一种由参与者的vPCG神经活动驱动的光标BCI，并在一系列目标选择任务中评估了其性能。所报道的vPCG光标BCI实现了快速校准（40秒）、精确（每秒2.90比特）的光标控制和点击。该参与者还使用BCI独立控制了自己的个人计算机。这些结果表明，将电极置于vPCG以优化言语解码，可能也是构建一种多模态BCI的可行策略，这种BCI既能实现基于言语的通信，又能通过光标和点击实现计算机控制。（BrainGate2临床试验注册号NCT00912041）
