Fung Stacey M, Ferrill Mary J
Medical Affairs, Protein Design Labs, Inc., Fremont CA 94555-3617, USA.
Ann Pharmacother. 2002 Mar;36(3):517-20. doi: 10.1345/aph.10311.
To evaluate the effect of granulocyte macrophage-colony stimulating factor (GM-CSF) in patients with oral mucositis.
Literature was accessed through MEDLINE (1966-June 2000) and bibliographic searches.
Published literature assessing the use of GM-CSF to treat or prevent oral mucositis was analyzed.
Reports of GM-CSF improving mucositis have been published; however, because of limitations in these reports, insufficient evidence confirms the benefits of GM-CSF. These preliminary studies provide a rationale to conduct well-designed, double-blind, randomized trials to evaluate the safety and efficacy of GM-CSF in the treatment and/or prevention of oral mucositis induced by chemotherapy and/or radiotherapy.
评估粒细胞巨噬细胞集落刺激因子（GM-CSF）对口腔黏膜炎患者的疗效。
通过MEDLINE（1966年至2000年6月）及文献检索获取文献。
分析已发表的评估GM-CSF用于治疗或预防口腔黏膜炎的文献。
已有关于GM-CSF改善黏膜炎的报道；然而，由于这些报道存在局限性，尚无充分证据证实GM-CSF的益处。这些初步研究为开展精心设计的双盲随机试验提供了理论依据，以评估GM-CSF在治疗和/或预防化疗和/或放疗引起的口腔黏膜炎方面的安全性和有效性。
