Smikie M F, Pascoe R W, Barton E, Morgan O, Christian N, Dowe G, Roye-Green K, Bailey V, James O
Department of Microbiology, University of the West Indies, Jamaica.
Clin Endocrinol (Oxf). 2001 Dec;55(6):805-8. doi: 10.1046/j.1365-2265.2001.01414.x.
Graves' disease is associated with different human leucocyte antigen (HLA) genes in different populations. This studywasdesigned to examinethe HLA class II associations with Graves' disease in Jamaicans.
One hundred and six Jamaicans with Graves' disease and 104 controls.
Oligotyping for HLA-DRB1, DRB3, DQA1 and DQB1 alleles was performed using the polymerase chain reaction sequence specific oligonucleotide probe (PCR-SSOP) technique. RESULTS The frequency of HLA-DRB3 *0101 was increased significantly in the patients compared to controls (38.7% vs. 19.2%; RR = 2.72; Pc < 0.015). The protective alleles for Graves' disease were DRB1 0901 (0.9% vs. 20.2%; RR = 0.04; Pc < 0.001), DRB11001 (0.0% vs. 11%; RR = 0.0%; Pc < 0.01) and DRB4 *0101 (0.0% vs. 12.5%; RR = 0.0; Pc < 0.05). A high female to male ratio of Graves' disease, 25 :1, was observed. Other associated autoimmune diseases were rare and no significant HLA class II associations were found with clinical markers of disease.
Jamaican patients with Graves' disease share the DRB3 *0101 susceptible allele and the DRB4 01 protective allele but not the susceptible haplotype DRB1 0301, DRB30101, DQA10501 with Caucasians.
在不同人群中，格雷夫斯病与不同的人类白细胞抗原（HLA）基因相关。本研究旨在检测牙买加人格雷夫斯病与HLA II类基因的关联。
106例患有格雷夫斯病的牙买加人和104例对照者。
采用聚合酶链反应序列特异性寡核苷酸探针（PCR-SSOP）技术对HLA-DRB1、DRB3、DQA1和DQB1等位基因进行寡核苷酸分型。
与对照组相比，患者中HLA-DRB3 *0101的频率显著增加（38.7%对19.2%；相对危险度=2.72；Pc<0.015）。格雷夫斯病的保护性等位基因是DRB1 0901（0.9%对20.2%；相对危险度=0.04；Pc<0.001）、DRB11001（0.0%对11%；相对危险度=0.0%；Pc<0.01）和DRB4 *0101（0.0%对12.5%；相对危险度=0.0；Pc<0.05）。观察到格雷夫斯病的男女比例很高，为25:1。其他相关自身免疫性疾病很少见，未发现HLA II类基因与疾病临床标志物有显著关联。
牙买加人格雷夫斯病患者与白种人共享DRB3 *0101易感等位基因和DRB4 01保护性等位基因，但不共享易感单倍型DRB1 0301、DRB30101、DQA10501。
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