通过中性2-氮杂二烯的分子内狄尔斯-阿尔德环加成反应合成源自吡咯烷、中氮茚和吲哚的氮杂多环化合物。
Synthesis of aza polycyclic compounds derived from pyrrolidine, indolizidine, and indole via intramolecular Diels-Alder cycloadditions of neutral 2-azadienes.
作者信息
Palacios Francisco, Alonso Concepción, Amezua Patricia, Rubiales Gloria
机构信息
Departamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco., Apartado 450, 01080 Vitoria, Spain.
出版信息
J Org Chem. 2002 Mar 22;67(6):1941-6. doi: 10.1021/jo016325v.
PMID:11895415
Abstract
A method for the preparation of novel oxaza and diaza polycyclic 9-oxa-4-azaphenanthrene, 5H-pyrido[2,3-a]pyrrolizine, 5H,6H-pyrido[3,2-g]indolizine, and 5H,6H-indeno[2,1-a]indole is described, based on tandem reactions: aza-Wittig reaction of N-vinylic phosphazenes with functionalized aldehydes and an intramolecular aza-Diels-Alder reaction.
摘要
描述了一种基于串联反应制备新型氧杂和氮杂多环化合物9-氧杂-4-氮杂菲、5H-吡啶并[2,3-a]吡咯嗪、5H,6H-吡啶并[3,2-g]吲哚嗪和5H,6H-茚并[2,1-a]吲哚的方法：N-乙烯基磷腈与官能化醛的氮杂维蒂希反应以及分子内氮杂狄尔斯-阿尔德反应。
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