衣原体肺炎在较少检查的血管中。
Chlamydia pneumoniae in infrequently examined blood vessels.
作者信息
Taylor-Robinson D, Thomas B J, Goldin R, Stanbridge R
机构信息
Department of Genitourinary Medicine, Imperial College School of Medicine, St Mary's Campus, Paddington, London, UK.
出版信息
J Clin Pathol. 2002 Mar;55(3):218-20. doi: 10.1136/jcp.55.3.218.
AIM
To determine the prevalence of Chlamydia pneumoniae DNA in infrequently examined blood vessels.
METHODS
Vessels obtained from 15 men and six women at coronary artery bypass surgery were tested by a nested polymerase chain reaction (PCR) assay for C pneumoniae DNA.
RESULTS
Chlamydia pneumoniae DNA was detected in four of six atheromatous ascending aorta specimens but in none of eight non-atheromatous aorta specimens, in six of 11 atheromatous internal mammary artery specimens but in none of seven non-atheromatous internal mammary artery specimens, in five of seven long saphenous vein specimens showing evidence of disease but in none of 12 specimens without evidence of disease, and in two of three previously grafted veins. Overall, C pneumoniae occurred significantly more often in diseased than in normal vessels (p = < 0.00001).
CONCLUSIONS
Chlamydia pneumoniae is often present in diseased areas of arteries, including the internal mammary arteries, and even in diseased areas of veins. It is not present in apparently healthy areas of either type of vessel.
目的
确定不常检查的血管中肺炎衣原体DNA的流行情况。
方法
对15名男性和6名女性在冠状动脉搭桥手术中获取的血管，采用巢式聚合酶链反应（PCR）检测肺炎衣原体DNA。
结果
在6个动脉粥样硬化升主动脉标本中有4个检测到肺炎衣原体DNA，但8个非动脉粥样硬化主动脉标本中均未检测到；在11个动脉粥样硬化乳内动脉标本中有6个检测到，而7个非动脉粥样硬化乳内动脉标本中均未检测到；在7个有病变迹象的大隐静脉标本中有5个检测到，而12个无病变迹象的标本中均未检测到；在3个先前移植的静脉中有2个检测到。总体而言，肺炎衣原体在病变血管中出现的频率显著高于正常血管（p = < 0.00001）。
结论
肺炎衣原体常存在于动脉的病变区域，包括乳内动脉，甚至静脉的病变区域。在这两种类型血管的明显健康区域均未发现。
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