Baker S R, Holdrege C T, McGregor D N
J Antibiot (Tokyo). 1979 May;32(5):468-71. doi: 10.7164/antibiotics.32.468.
The synthesis of a new penicillin, disodium D-6-[alpha-(1,2,4-triazine-3,5-dione-6-carboxyamido)-4-hydroxyphenylacetamido]penicillanate (BL-P1908), is described. The compound shows superior in vitro activity against Pseudomonas aeruginosa compared to carbenicillin and ticarcillin and produces higher intramuscular serum levels in mice than does carbenicillin.
本文描述了一种新型青霉素D-6-[α-(1,2,4-三嗪-3,5-二酮-6-羧酰胺基)-4-羟基苯乙酰氨基]青霉烷酸钠盐（BL-P1908）的合成。与羧苄西林和替卡西林相比，该化合物对铜绿假单胞菌显示出更优异的体外活性，并且在小鼠体内产生的肌内血清水平高于羧苄西林。
