磺基头孢菌素的免疫交叉反应性。

Immunological cross-reactivities of sulfocephalosporins.

作者信息

Tsuchiya K, Shiho O, Kondo M

出版信息

J Antibiot (Tokyo). 1979 May;32(5):488-95. doi: 10.7164/antibiotics.32.488.

DOI:10.7164/antibiotics.32.488

Abstract

The immunological cross-reaction among sulfocephalosporins (cefsulodin, SFC-I, SFC-II), cephaloridine, sulbenicillin, penicillin G and 7-aminocephalosporanic acid has been investigated. A specific antibody was produced in rabbits against several structurally related haptens. The sensitization was conducted with a hapten-human serum albumin conjugate, which was prepared in an alkaline solution, with Freund's complete adjuvant. A cross-reaction was claraly demonstrated between sulfocephalosporins and sulbenicillin, but not between sulfocephalosporins and cephaloridine, penicillin G or 7-aminocephalosporanic acid.

摘要

已对磺基头孢菌素（磺苄西林、SFC-I、SFC-II）、头孢噻啶、磺苄西林、青霉素G和7-氨基头孢烷酸之间的免疫交叉反应进行了研究。用几种结构相关的半抗原在兔体内产生了特异性抗体。致敏是用在碱性溶液中制备的半抗原-人血清白蛋白结合物与弗氏完全佐剂进行的。磺基头孢菌素与磺苄西林之间明确显示有交叉反应，但磺基头孢菌素与头孢噻啶、青霉素G或7-氨基头孢烷酸之间没有交叉反应。