Wendelin-Saarenhovi M L, Isoaho R E, Hartiala J J, Helenius H Y, Kivelä S-L, Löppönen M K, Hietanen E K
Department of Clinical Physiology Nuclear Medicine and Positron Emission Tomography, Turku University Central Hospital, Turku, Finland.
J Hum Hypertens. 2002 Mar;16(3):177-84. doi: 10.1038/sj.jhh.1001318.
The objective of this study was to determine the normal values and characteristics of 24-h ambulatory blood pressure (ABP) and to describe the ABP level of treated hypertensive subjects in an older Finnish population. ABP was measured in 502 randomly selected subjects aged 64 years or over living in a Finnish municipality (mean age 70 years, range 64-87 years). A total of 211 subjects did not have blood pressure (BP) affecting medication. ABP measurements were taken every 30 min for 24 h, and the day- and night-time periods were diary-based. The results were that in untreated subjects, the average office BP was 134/82 +/- 16/9 (s.d.) mm Hg for men and 140/81 +/- 18/8 mm Hg for women. The 24-h average BP was 120/75 +/- 14/8 mm Hg (95th percentile upper limit 145/93 mm Hg) for men and 125/75 +/- 15/7 (95th = 154/89 mm Hg) for women. The daytime averages were 127/78 +/- 12/7 mm Hg (95th = 154/99 mm Hg) and 131/78 +/- 15/7 mm Hg (95th = 158/91 mm Hg) for men and women, respectively. The ABP daytime value of 130/83 mm Hg corresponded best to the office BP value of 140/90 mm Hg. All BP values were significantly higher in the treated hypertensive group compared to the normotensive group. Night-time BP was markedly lower than daytime BP, and no difference in circadian variability was found between the normotensive and hypertensive subjects. Both office and ambulatory BPs were significantly higher in women than in men. This study provides sex-specific normal values for ABP in a 64 to 87-year-old age group. The normal values of ABP were markedly lower than the office BP values. Hypertensives, even when treated, tended to have elevated values.
本研究的目的是确定24小时动态血压（ABP）的正常值和特征，并描述芬兰老年人群中接受治疗的高血压患者的ABP水平。对芬兰一个市镇中随机选取的502名64岁及以上的受试者（平均年龄70岁，范围64 - 87岁）进行了ABP测量。共有211名受试者没有服用影响血压（BP）的药物。ABP测量每30分钟进行一次，持续24小时，白天和夜间时段以日记为基础。结果显示，在未接受治疗的受试者中，男性的平均诊室血压为134/82±16/9（标准差）mmHg，女性为140/81±18/8 mmHg。男性的24小时平均血压为120/75±14/8 mmHg（第95百分位数上限为145/93 mmHg），女性为125/75±15/7（第95百分位数 = 154/89 mmHg）。男性和女性的白天平均血压分别为127/78±12/7 mmHg（第95百分位数 = 154/99 mmHg）和131/78±15/7 mmHg（第95百分位数 = 158/91 mmHg）。ABP白天值130/83 mmHg与诊室血压值140/90 mmHg最为对应。与血压正常组相比，接受治疗的高血压组的所有血压值均显著更高。夜间血压明显低于白天血压，血压正常者和高血压患者之间昼夜变异性无差异。女性的诊室血压和动态血压均显著高于男性。本研究提供了64至87岁年龄组ABP的性别特异性正常值。ABP的正常值明显低于诊室血压值。高血压患者即使接受治疗后，血压值仍往往偏高。
