Worrell L Andre, Thorp James W, Tucker Richard, McKinley Leslie Turner, Chen James, Chng Yi-Mei, Vohr Betty R
Department of Pediatrics, Women and Infants Hospital and Brown Medical School, Providence, RI 02905, USA.
J Perinatol. 2002 Mar;22(2):112-9. doi: 10.1038/sj.jp.7210680.
The purpose of this study was to determine the impact of introducing a high-nutrient transitional formula (TF) for use after discharge on the growth and development of premature infants.
This was a cohort study of all surviving infants with a birth weight < or =1250 g admitted to the neonatal intensive care unit between January 1, 1995 and December 31, 1996. Infants with major congenital abnormalities were excluded. There were 180 infants discharged, including 66 on TF and 114 on standard formulas for full-term infants.
Use of TF started the week before discharge, and increased from 10% in 1995 to 66% in 1996 (p<0.001). Regression analyses controlling for multiple confounders identified TF as a significant contributor to improved weight at 3 months and length at 18 months. Bayley developmental scores were not affected.
Introduction of a TF for very-low-birth-weight infants resulted in improved growth after discharge.
本研究旨在确定出院后使用高营养过渡配方奶粉（TF）对早产儿生长发育的影响。
这是一项队列研究，研究对象为1995年1月1日至1996年12月31日期间入住新生儿重症监护病房、出生体重≤1250g的所有存活婴儿。患有严重先天性异常的婴儿被排除在外。共有180名婴儿出院，其中66名使用TF，114名使用足月婴儿标准配方奶粉。
TF在出院前一周开始使用，使用率从1995年的10%增至1996年的66%（p<0.001）。控制多个混杂因素的回归分析表明，TF是3个月时体重增加和18个月时身长增加的重要因素。贝利发育评分未受影响。
为极低出生体重婴儿引入TF可改善出院后的生长情况。
