Chhina Satbir, Peverini Ricardo L, Deming Douglas D, Hopper Andrew O, Hashmi Aijaz, Vyhmeister Nidia R
Doctor's Hospital, Laredo, TX, USA.
J Perinatol. 2002 Mar;22(2):144-8. doi: 10.1038/sj.jp.7210613.
To examine the effect of cisapride on the corrected QT (QTc) interval in infants over a 14-day period.
A prospective cohort study of infants receiving cisapride (0.8 mg/kg per day). Twelve-lead electrocardiograms were obtained before and 3, 5, 7, and 14 days after cisapride initiation.
Fifty infants completed the study; none had arrhythmias. Fifteen of 50 infants (30%) developed QTc interval > or =450 msec; QTc interval normalized in 13 of 15 infants. Infants with QTc interval on day 3 > or =2 standard deviations above the mean baseline QTc interval (401+40 msec) were more likely to develop prolonged QTc interval (p<0.0001).
QTc interval prolongation was noted in 30% of infants. Subsequently, the majority of those infants had QTc interval normalization by day 14 of cisapride therapy. QTc interval 3 days following cisapride initiation may identify infants at risk for transient QTc interval prolongation. With appropriate monitoring, hospitalized infants receiving cisapride may have improved gastrointestinal motility without cardiac morbidity.
研究西沙必利在14天内对婴儿校正QT（QTc）间期的影响。
对接受西沙必利（每天0.8毫克/千克）治疗的婴儿进行前瞻性队列研究。在开始使用西沙必利之前以及用药后3天、5天、7天和14天记录12导联心电图。
50名婴儿完成了研究；无一例发生心律失常。50名婴儿中有15名（30%）QTc间期≥450毫秒；15名婴儿中有13名QTc间期恢复正常。用药后3天QTc间期≥平均基线QTc间期（401±40毫秒）2个标准差以上的婴儿更易出现QTc间期延长（p<0.0001）。
30%的婴儿出现QTc间期延长。随后，大多数婴儿在西沙必利治疗14天时QTc间期恢复正常。开始使用西沙必利3天后的QTc间期可能有助于识别有短暂QTc间期延长风险的婴儿。通过适当监测，住院接受西沙必利治疗的婴儿可改善胃肠动力且无心脏并发症。
