Conklin Kenneth A
Department of Anesthesiology, UCLA School of Medicine, Center for the Health Sciences, Box 951778, Los Angeles, CA 90095-1778, USA.
Altern Med Rev. 2002 Feb;7(1):4-21.
Preclinical studies have shown that certain polyunsaturated fatty acids may actually enhance the cytotoxicity of several antineoplastic agents and the anticancer effects of radiotherapy. These effects are possibly mediated by incorporation of the polyunsaturated fatty acids into cancer cell membranes, thus altering the physical and functional properties. In addition, certain polyunsaturated fatty acids may also reduce or prevent some of the side effects of these therapies, and administering antioxidants to prevent polyunsaturated fatty acid-induced oxidative stress may further enhance the impact of chemotherapy and radiation.
临床前研究表明，某些多不饱和脂肪酸实际上可能增强几种抗肿瘤药物的细胞毒性以及放疗的抗癌效果。这些作用可能是通过将多不饱和脂肪酸掺入癌细胞膜，从而改变其物理和功能特性来介导的。此外，某些多不饱和脂肪酸还可能减少或预防这些疗法的一些副作用，并且给予抗氧化剂以防止多不饱和脂肪酸诱导的氧化应激可能会进一步增强化疗和放疗的效果。
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