Lavasanifar Afsaneh, Samuel John, Kwon Glen S
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2N8, Canada.
Adv Drug Deliv Rev. 2002 Feb 21;54(2):169-90. doi: 10.1016/s0169-409x(02)00015-7.
Block copolymer micelles encapsulate water insoluble drugs by chemical and physical means, and they may target therapeutics to their site of action in a passive or active way. In this review, we focus on micelles self-assembled from poly(ethylene oxide)-block-poly(L-amino acid) (PEO-b-PLAA). A common theme in these studies is the chemical modification of the core-forming PLAA block used to adjust and optimize the properties of PEO-b-PLAA micelles for drug delivery. Micelle-forming block copolymer-drug conjugates, micellar nanocontainers and polyion complex micelles have been obtained that mimic functional aspects of biological carriers, namely, lipoproteins and viruses. PEO-b-PLAA micelles may be advantageous in terms of safety, stability, and scale-up.
嵌段共聚物胶束通过化学和物理手段包裹水不溶性药物，并且它们可以以被动或主动的方式将治疗剂靶向作用部位。在本综述中，我们重点关注由聚（环氧乙烷）-嵌段-聚（L-氨基酸）（PEO-b-PLAA）自组装形成的胶束。这些研究中的一个共同主题是对形成核心的PLAA嵌段进行化学修饰，以调节和优化PEO-b-PLAA胶束用于药物递送的性能。已经获得了形成胶束的嵌段共聚物-药物缀合物、胶束纳米容器和聚离子复合物胶束，它们模拟了生物载体（即脂蛋白和病毒）的功能方面。PEO-b-PLAA胶束在安全性、稳定性和放大生产方面可能具有优势。
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