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岩白菜素及其衍生物：癌症治疗的设计、合成与潜在递送系统

Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy.

作者信息

Danquah Michael

机构信息

Department of Pharmaceutical Sciences, Chicago State University, 9501 South King Drive, Chicago, IL 60628, USA.

出版信息

Pharmaceuticals (Basel). 2022 Sep 9;15(9):1131. doi: 10.3390/ph15091131.

DOI:10.3390/ph15091131
PMID:36145352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9505931/
Abstract

Embelin is a naturally occurring benzoquinone that inhibits the growth of cancer cells, making it a potent anticancer drug. However, the low water solubility of embelin restricts its clinical applicability. This review provides a concise summary and in-depth analysis of the published literature on the design and synthesis of embelin derivatives possessing increased aqueous solubility and superior therapeutic efficacy. In addition, the potential of drug delivery systems to improve the anticancer capabilities of embelin and its derivatives is discussed.

摘要

紫铆因是一种天然存在的苯醌，它能抑制癌细胞的生长，使其成为一种有效的抗癌药物。然而，紫铆因的低水溶性限制了其临床应用。这篇综述对已发表的关于具有增加的水溶性和卓越治疗效果的紫铆因衍生物的设计与合成的文献进行了简要总结和深入分析。此外，还讨论了药物递送系统提高紫铆因及其衍生物抗癌能力的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/f3b30f07f6ac/pharmaceuticals-15-01131-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/2ab27e093e78/pharmaceuticals-15-01131-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/bf5df71dc86f/pharmaceuticals-15-01131-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/05e4d90830fd/pharmaceuticals-15-01131-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/8d413c19b0a3/pharmaceuticals-15-01131-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/9681c84f57ed/pharmaceuticals-15-01131-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/0de31722f546/pharmaceuticals-15-01131-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/b26c46976c14/pharmaceuticals-15-01131-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/49d857211a76/pharmaceuticals-15-01131-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/f3b30f07f6ac/pharmaceuticals-15-01131-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/2ab27e093e78/pharmaceuticals-15-01131-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/bf5df71dc86f/pharmaceuticals-15-01131-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/05e4d90830fd/pharmaceuticals-15-01131-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/8d413c19b0a3/pharmaceuticals-15-01131-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/9681c84f57ed/pharmaceuticals-15-01131-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/0de31722f546/pharmaceuticals-15-01131-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/b26c46976c14/pharmaceuticals-15-01131-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/49d857211a76/pharmaceuticals-15-01131-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c567/9505931/f3b30f07f6ac/pharmaceuticals-15-01131-g003.jpg

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A Fluoro Derivative of Embelin, as Potent B-RAF Inhibitor in Melanoma.一种杨梅素的氟代衍生物，作为黑色素瘤中有效的 B-RAF 抑制剂。
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