Hilakivi-Clarke Leena, Cabanes Anna, Olivo Susan, Kerr Leslie, Bouker Kerrie B, Clarke Robert
Lombardi Cancer Center and Department of Oncology, Georgetown University, Room W405, 3970 Reservoir Road NW, Washington, DC 20007, USA.
J Steroid Biochem Mol Biol. 2002 Feb;80(2):163-74. doi: 10.1016/s0960-0760(01)00184-4.
The etiology of breast cancer is closely linked to the female hormone estrogen, with high life-time exposure being suggested to increase breast cancer risk [Nature 303 (1983) 767]. However, there appears to be a disparity between studies attempting to establish an association between high estrogen levels and breast cancer risk. This disparity becomes smaller by taking into consideration a timing factor, and we propose that estrogens can increase, decrease, or have no effect on breast cancer risk, depending on the timing of estrogen exposure. We further propose that the timing of estrogenic exposures may play at least as important a role in affecting breast cancer risk as life-time exposure.
乳腺癌的病因与女性荷尔蒙雌激素密切相关，长期高暴露被认为会增加患乳腺癌的风险[《自然》303 (1983) 767]。然而，在试图确定高雌激素水平与乳腺癌风险之间关联的研究中，似乎存在差异。考虑到一个时间因素后，这种差异会变小，并且我们提出，雌激素对乳腺癌风险的影响可能会增加、降低或没有影响，这取决于雌激素暴露的时间。我们进一步提出，雌激素暴露的时间在影响乳腺癌风险方面可能至少与终生暴露起着同样重要的作用。
