阿尔茨海默病生物标志物：它们在诊断和临床试验中的价值。

Alzheimer's disease biomarkers: their value in diagnosis and clinical trials.

作者信息

Small David H

机构信息

Laboratory of Molecular Neurobiology, Department of Pathology, University of Melbourne, Victoria 3010, Australia.

出版信息

Front Biosci. 2002 Apr 1;7:d986-8. doi: 10.2741/A824.

DOI:10.2741/A824

PMID:11897567

Abstract

Biomarkers of Alzheimer's disease may be useful, not only for early diagnosis of the disease, but also for monitoring the progress of drug trials. A number of plasma and cerebrospinal fluid markers are reportedly altered in Alzheimer's disease. So far, no single biomarker can be used to diagnose Alzheimer's disease definitively. Nevertheless, it may eventually be possible to use several markers in combination to obtain sufficient diagnostic accuracy. However, for this to be the case, new specific biomarkers may need to be identified.

摘要

阿尔茨海默病的生物标志物可能不仅对该疾病的早期诊断有用，而且对监测药物试验的进展也有用。据报道，阿尔茨海默病患者的一些血浆和脑脊液标志物会发生改变。到目前为止，没有单一的生物标志物可用于明确诊断阿尔茨海默病。然而，最终有可能联合使用多种标志物以获得足够的诊断准确性。然而，要实现这一点，可能需要识别新的特异性生物标志物。