Fourteen-member macrolides suppress interleukin-8 production but do not promote apoptosis of activated neutrophils.

作者信息

Tsuchihashi Yoshiko, Oishi Kazunori, Yoshimine Hiroyuki, Suzuki Shoichi, Kumatori Atsushi, Sunazuka Toshiaki, Omura Satoshi, Matsushima Kouji, Nagatake Tsuyoshi

机构信息

Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.

出版信息

Antimicrob Agents Chemother. 2002 Apr;46(4):1101-4. doi: 10.1128/AAC.46.4.1101-1104.2002.

A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils. These data suggest that 14-member macrolides achieve clinical efficacy for chronic airway diseases partly by suppressing IL-8 production by activated neutrophils, but not by enhancing apoptosis in these cells.