新型头孢菌素BMS-247243对葡萄球菌以外的其他微生物的体外和体内活性

In vitro and in vivo activities of a novel cephalosporin, BMS-247243, against organisms other than staphylococci.

作者信息

Clark Junius, Fung-Tomc Joan C, Minassian Beatrice, Tsai Yuan-Hwang, Yang Hyekyung, Huczko Elizabeth, Kolek Benjamin, Chaniewski Susan, Ferraro Cheryl, Drain Rebecca, Gradelski Elizabeth, Bonner Daniel P

机构信息

Department of Microbiology, Bristol-Myers Squibb Co., Wallingford, Connecticut 06492, USA.

出版信息

Antimicrob Agents Chemother. 2002 Apr;46(4):1108-11. doi: 10.1128/AAC.46.4.1108-1111.2002.

DOI:10.1128/AAC.46.4.1108-1111.2002

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC127083/

Abstract

BMS-247243, a novel cephalosporin inhibitory for methicillin-resistant staphylococci, primarily has activity against gram-positive bacteria. The activities of BMS-247243, cefotaxime, and ceftriaxone against streptococci and Streptococcus pneumoniae were similar. BMS-247243 inhibits Enterococcus faecalis but not Enterococcus faecium. BMS-247243 also inhibits many inherently vancomycin-resistant species (Leuconstoc, Lactobacillus, Pediococcus) and anaerobic gram-positive bacteria.

摘要

BMS-247243是一种新型头孢菌素，对耐甲氧西林葡萄球菌具有抑制作用，主要对革兰氏阳性菌有活性。BMS-247243、头孢噻肟和头孢曲松对链球菌和肺炎链球菌的活性相似。BMS-247243抑制粪肠球菌，但不抑制屎肠球菌。BMS-247243还抑制许多固有耐万古霉素的菌种（明串珠菌属、乳杆菌属、片球菌属）和厌氧革兰氏阳性菌。

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本文引用的文献

1

In vitro and in vivo activities of a novel cephalosporin, BMS-247243, against methicillin-resistant and -susceptible staphylococci.新型头孢菌素BMS-247243对耐甲氧西林和甲氧西林敏感葡萄球菌的体外及体内活性

Antimicrob Agents Chemother. 2002 Apr;46(4):971-6. doi: 10.1128/AAC.46.4.971-976.2002.

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