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果蝇胚胎编程2:从基因型到表型。

Programming the Drosophila embryo 2: from genotype to phenotype.

作者信息

Bodnar J W, Bradley M K

机构信息

Division of Science, Villa Julie College, Stevenson, MD 21153, USA.

出版信息

Cell Biochem Biophys. 2001;34(2):153-90. doi: 10.1385/CBB:34:2:153.

Abstract

Although development is a single hierarchical process, scientists tend to study only one level at a time: molecular, cellular, or organismal. The data and theory are available to integrate molecular, cellular, and organismal levels into a series of maps for development of the Drosophila embryo. These maps link the transcriptional cascade with mitotic and phenotypic fate maps to trace hierarchical mechanisms of development from the genotype in the egg to the phenotype in the larva.

摘要

尽管发育是一个单一的层级过程,但科学家们往往一次只研究一个层次:分子、细胞或机体层次。现有数据和理论可将分子、细胞和机体层次整合到一系列果蝇胚胎发育图谱中。这些图谱将转录级联与有丝分裂和表型命运图谱联系起来,以追踪从卵中的基因型到幼虫中的表型的层级发育机制。

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