VanHook Annalisa, Letsou Anthea
Department of Human Genetics, University of Utah, Salt Lake City, Utah 84132, USA.
Dev Dyn. 2008 Jan;237(1):28-38. doi: 10.1002/dvdy.21405.
Dorsal closure and head involution are complex morphogenetic processes that occur nearly simultaneously, midway through Drosophila embryonic development. While dorsal closure has been studied extensively in terms of both its morphology and genetics, head involution has not been described comprehensively. A thorough review of the literature nonetheless reveals considerable information regarding the genetic components of head involution. In several instances, authors have made explicit references to head involution in regard to mutant phenotypes; in others, we have made this connection. Here we collect, catalogue, and discuss published head involution studies. In considering and integrating the data, an enhanced appreciation of the molecular mechanisms underlying head involution and its molecular kinship with dorsal closure has emerged.
背侧闭合和头部内卷是复杂的形态发生过程，几乎同时发生在果蝇胚胎发育的中期。虽然背侧闭合在形态学和遗传学方面都得到了广泛研究，但头部内卷尚未得到全面描述。然而，对文献的全面回顾揭示了有关头部内卷遗传成分的大量信息。在一些情况下，作者在提及突变体表型时明确提到了头部内卷；在其他情况下，我们建立了这种联系。在这里，我们收集、编目并讨论已发表的关于头部内卷的研究。在考虑和整合这些数据的过程中，我们对头部内卷的分子机制及其与背侧闭合的分子亲缘关系有了更深入的认识。
