Meier Christoph R, Schmitz Stephen, Jick Hershel
Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Switzerland.
Pharmacotherapy. 2002 Mar;22(3):303-9. doi: 10.1592/phco.22.5.303.33189.
To explore the association between exposure to acetaminophen (paracetamol) or nonsteroidal antiinflammatory drugs (NSAIDs) and risk of developing ovarian, breast, or colon cancer.
Retrospective case-control study
General practice offices.
Four hundred eighty-three women with ovarian cancer and 1877 women matched for age, years of medical history in computer record, general practice attended, and calendar time; 3706 women with breast cancer and 14,155 matched control subjects; and 635 women with colon cancer and 2434 matched control subjects.
United Kingdom-based General Practice Research Database was searched for women aged 50-89 years with a first-time diagnosis of ovarian, breast, or colon cancer and for matched controls to assess prescription analgesic exposure.
Regular acetaminophen exposure (> or = 30 prescriptions) was associated with a slightly decreased risk of developing breast (odds ratio [OR] 0.8, 95% confidence interval [CI] 0.7-1.0) but not ovarian (OR 1.0, 95% CI 0.6-1.5) or colon (OR 1.0, 95% Cl 0.7-1.4) cancer. Regular NSAID exposure was associated with a reduced risk of colon (OR 0.5, 95% CI 0.3-0.9) but not ovarian or breast cancer.
We found no evidence for a decreased ovarian cancer risk for women with regular acetaminophen or NSAID exposure.
探讨对乙酰氨基酚（扑热息痛）或非甾体抗炎药（NSAIDs）的暴露与卵巢癌、乳腺癌或结肠癌发病风险之间的关联。
回顾性病例对照研究
全科医疗诊所
483例卵巢癌女性患者以及1877例在年龄、计算机记录中的病史年限、就诊的全科医疗诊所和日历时间方面与之匹配的女性；3706例乳腺癌女性患者以及14155例匹配的对照对象；635例结肠癌女性患者以及2434例匹配的对照对象。
在基于英国的全科医疗研究数据库中搜索年龄在50 - 89岁之间首次诊断为卵巢癌、乳腺癌或结肠癌的女性以及匹配的对照对象，以评估处方镇痛药的暴露情况。
经常使用对乙酰氨基酚（≥30张处方）与患乳腺癌风险略有降低相关（比值比[OR]为0.8，95%置信区间[CI]为0.7 - 1.0），但与卵巢癌（OR为1.0，95% CI为0.6 - 1.5）或结肠癌（OR为1.0，95% CI为0.7 - 1.4）无关。经常使用非甾体抗炎药与患结肠癌风险降低相关（OR为0.5，95% CI为0.3 - 0.9），但与卵巢癌或乳腺癌无关。
我们没有发现证据表明经常使用对乙酰氨基酚或非甾体抗炎药的女性患卵巢癌风险降低。
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