Yamamoto Y, Gaynor R B
Department of Medicine, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas 75390-8594, USA.
Curr Mol Med. 2001 Jul;1(3):287-96. doi: 10.2174/1566524013363816.
The NF-kappaB family consists of a group of inducible transcription factors which regulate immune and inflammatory responses and protect cells from undergoing apoptosis in response to cellular stress. A number of signal transduction cascades can activate the NF-kappaB pathway to result in the translocation of the NF-kappaB proteins from the cytoplasm to the nucleus where they activate the expression of specific cellular genes. In this review, we discuss cellular genes which are regulated by NF-kappaB and disease states which are associated with constitutive activation of the NF-kappaB pathway. Strategies to prevent prolonged activation of the NF-kappaB pathway are also discussed.
核因子κB（NF-κB）家族由一组可诱导的转录因子组成，这些转录因子调节免疫和炎症反应，并保护细胞在受到细胞应激时免于凋亡。许多信号转导级联反应可激活NF-κB途径，导致NF-κB蛋白从细胞质转运至细胞核，在细胞核中它们激活特定细胞基因的表达。在本综述中，我们讨论了受NF-κB调节的细胞基因以及与NF-κB途径的组成性激活相关的疾病状态。还讨论了预防NF-κB途径长期激活的策略。
