Xu Yaxi, Xin Jianzeng, Sun Yupei, Wang Xuyan, Sun Lili, Zhao Feng, Niu Changshan, Liu Sheng
School of Pharmacy, Yantai University, Yantai 264005, China.
School of Life Sciences, Yantai University, Yantai 264005, China.
Pharmaceuticals (Basel). 2024 Apr 8;17(4):472. doi: 10.3390/ph17040472.
Sepsis-induced acute lung injury (ALI), characterized by widespread lung dysfunction, is associated with significant morbidity and mortality due to the lack of effective pharmacological treatments available clinically. Small-molecule compounds derived from natural products represent an innovative source and have demonstrated therapeutic potential against sepsis-induced ALI. These natural small molecules may provide a promising alternative treatment option for sepsis-induced ALI. This review aims to summarize the pathogenesis of sepsis and potential therapeutic targets. It assembles critical updates (from 2014 to 2024) on natural small molecules with therapeutic potential against sepsis-induced ALI, detailing their sources, structures, effects, and mechanisms of action.
脓毒症诱导的急性肺损伤（ALI）以广泛的肺功能障碍为特征，由于临床上缺乏有效的药物治疗，其发病率和死亡率都很高。天然产物衍生的小分子化合物是一种创新来源，并已显示出对脓毒症诱导的ALI的治疗潜力。这些天然小分子可能为脓毒症诱导的ALI提供一种有前景的替代治疗选择。本综述旨在总结脓毒症的发病机制和潜在治疗靶点。它汇集了（2014年至2024年）关于对脓毒症诱导的ALI具有治疗潜力的天然小分子的重要更新，详细介绍了它们的来源、结构、作用和作用机制。
