Maslova L N, Bulygina V V
Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russia.
Zh Vyssh Nerv Deiat Im I P Pavlova. 2002 Jan-Feb;52(1):97-103.
Immediate and long-lasting effects of chronic stress during prepubertal period (21-32 postnatal days) on anxiety- and depression-related behavior were studied in Wistar and ISIAH (inherited stress-induced arterial hypertension) rats. Significant interstrain differences were found. Both juvenile and adult ISIAH rats were less anxious in the elevated plus-maze and less depressed in the forced swimming test. Immediate effects of the prepubertal stress were similar in both rat strains and depended on the type of stimulation. Long-lasting effects were genotype-dependent. Chronic prepubertal handling exerted an anxiolytic effect in young ISIAH and Wistar rats and adult Wistar rats. Immediate anxiogenic effect of prepubertal unpredictable stress was preserved only in adult ISIAH rats. Depression-related behavior was intensified by the unpredictable stress in young animals, whereas the long-lasting effect was observed only in adult hypertensive rats.
研究了青春期前（出生后21 - 32天）慢性应激对Wistar大鼠和ISIAH（遗传性应激诱导性动脉高血压）大鼠焦虑和抑郁相关行为的即时和长期影响。发现了显著的品系间差异。幼年和成年ISIAH大鼠在高架十字迷宫中焦虑程度较低，在强迫游泳试验中抑郁程度较低。青春期前应激的即时影响在两种大鼠品系中相似，且取决于刺激类型。长期影响则依赖于基因型。青春期前的慢性处理对幼年ISIAH大鼠、Wistar大鼠和成年Wistar大鼠具有抗焦虑作用。青春期前不可预测应激的即时致焦虑作用仅在成年ISIAH大鼠中存在。不可预测应激使幼年动物的抑郁相关行为加剧，而长期影响仅在成年高血压大鼠中观察到。
