Anderson Mark E
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6300, USA.
J Cardiovasc Electrophysiol. 2002 Feb;13(2):195-7. doi: 10.1046/j.1540-8167.2002.00195.x.
Calmodulin and the Philosopher's Stone. It has been recognized for some time that intracellular Ca2+ ([Ca2+]i) can contribute to the genesis of cardiac arrhythmias, but understanding of the molecular signaling machinery that links disordered [Ca2+]i to arrhythmias has been lacking. Exciting recent work has focused on the ubiquitous intracellular Ca2+-binding protein calmodulin. Calmodulin is a molecular sensor that can translate increases in [Ca2+]i into modulatory signals for ion channels and activate other Ca2+-dependent signaling molecules. This article will examine the implications of these recent findings for arrhythmogenesis and the development of new antiarrhythmic therapies.
钙调蛋白与点金石。一段时间以来，人们已经认识到细胞内钙离子（[Ca2+]i）可促成心律失常的发生，但对于将紊乱的[Ca2+]i与心律失常联系起来的分子信号传导机制仍缺乏了解。最近令人兴奋的研究工作聚焦于普遍存在的细胞内钙离子结合蛋白钙调蛋白。钙调蛋白是一种分子传感器，它能将[Ca2+]i的增加转化为离子通道的调节信号，并激活其他钙离子依赖的信号分子。本文将探讨这些最新发现对心律失常发生机制及新型抗心律失常疗法发展的意义。
