Lopaschuk G D
Cardiovascular Research Group, University of Alberta, Edmonton, Canada.
Adv Exp Med Biol. 2001;498:155-65. doi: 10.1007/978-1-4615-1321-6_21.
Increased fatty acid metabolism can decrease cardiac function and efficiency, and may therefore contribute to the outcome of ischemic injury in the diabetic. Alterations in the control of myocardial malonyl CoA levels is an important contributing factor to these high fatty acid oxidation rates. This includes alterations in AMPK, ACC, and MCD activity in the diabetic rat heart. A further understanding of how malonyl CoA controls fatty acid oxidation in the diabetic heart should help identify new targets for pharmacological intervention which decreases the reliance of the heart on fatty acid oxidation, and ultimately improves heart function.
脂肪酸代谢增加会降低心脏功能和效率，因此可能导致糖尿病患者缺血性损伤的后果。心肌丙二酰辅酶A水平调控的改变是这些高脂肪酸氧化率的一个重要促成因素。这包括糖尿病大鼠心脏中AMPK、ACC和MCD活性的改变。进一步了解丙二酰辅酶A如何控制糖尿病心脏中的脂肪酸氧化，应有助于确定新的药物干预靶点，从而降低心脏对脂肪酸氧化的依赖，并最终改善心脏功能。
