正常孕妇阴道中多形核白细胞数量以及白细胞介素-8和粒细胞弹性蛋白酶浓度的变化。
Changes in the number of polymorphonuclear leukocytes and concentrations of IL-8 and granulocyte elastase in the vaginas of normal pregnant women.
作者信息
Yamada Tetsuo, Minakami Hisanori, Matsubara Shigeki, Kohmura Yasuhiro, Aoya Toshio, Sato Ikuo
机构信息
Department of Obstetrics and Gynecology, Jichi Medical School, Minamikawachimachi, Tochigi, Japan.
出版信息
Am J Reprod Immunol. 2002 Feb;47(2):98-103. doi: 10.1034/j.1600-0897.2002.1o012.x.
PROBLEM
It is unknown whether the number of vaginal polymorphonuclear leukocytes (vPMNs) of healthy pregnant women changes during pregnancy.
METHOD OF STUDY
We studied 23 women after 14.7 +/- 3.6 weeks, 37 women after 25.2 +/- 3.1 weeks, and 26 women after 32.9 +/- 2.0 weeks of gestation. Numbers of total vPMNs, viable vPMNs, dead vPMNs, percentage viability of vPMNs, and concentrations of IL-8 and elastase activity were determined in vaginal washings.
RESULTS
The vPMNs, including viable and dead vPMNs, significantly increased with advancing gestation from 9.9 +/- 8.6 x 10(5) to 13.1 +/- 13.4 x 10(5), and to 27.1 +/- 26.6 x 10(5) (r=0.315, P < 0.01). Vaginal IL-8 significantly increased with advancing gestation. However, increases in vaginal elastase activity did not occur.
CONCLUSIONS
These results suggested that an increase in vPMNs is an early event, and that the increase in vaginal elastase activity is a late event in relation to the ripening of the uterine cervix.
问题
健康孕妇阴道多形核白细胞（vPMNs）数量在孕期是否会发生变化尚不清楚。
研究方法
我们研究了妊娠14.7±3.6周后的23名女性、25.2±3.1周后的37名女性以及32.9±2.0周后的26名女性。测定了阴道灌洗液中vPMNs总数、存活vPMNs、死亡vPMNs、vPMNs存活百分比以及IL-8浓度和弹性蛋白酶活性。
结果
包括存活和死亡vPMNs在内的vPMNs数量随着孕周增加而显著增加，从9.9±8.6×10⁵增至13.1±13.4×10⁵，再增至27.1±26.6×10⁵（r = 0.315，P < 0.01）。阴道IL-8水平随孕周增加而显著升高。然而，阴道弹性蛋白酶活性并未增加。
结论
这些结果表明，vPMNs数量增加是早期事件，而阴道弹性蛋白酶活性增加是与子宫颈成熟相关的晚期事件。
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