Chimura T
Department of Obstetrics and Gynecology, Shirataka Hospital.
Jpn J Antibiot. 1997 May;50(5):474-8.
In 95 patients with abnormal vaginal and cervical secreta (49 pregnant women and 46 non-pregnant women), the relation between intravaginal flora and intravaginal granulocyte elastase (Elastase) and pH was investigated. The results were as follows. 1) Gram-positive bacteria were detected in the vaginal secreta at a high rate (87/144, 60.4%), and it mainly consisted of Lactobacillus sp. (67/142, 46.5%). It was followed anaerobia (26/144, 18.1%) and fungi (26/144, 18.1%). 2) The patients with cervicitis or vaginitis had higher elastase value (6.65-6.69 micrograms/ml) than the ones with vaginal erosion, and the patients who showed an intravaginal pH value not lower than 5.0 had significantly increased elastase value (6.44 +/- 1.40 micrograms/ml) than the patients who showed the values 4.5 or higher. 3) Regarding the relation between the detected bacteria and elastase values, elastase values were higher in the patients infected by anaerobia (6.58 +/- 1.40 micrograms/ml), Gram-negative bacteria (6.01 +/- 3.61 micrograms/ml), Gram-positive bacteria (5.02 +/- 0.94 micrograms/ml) and fungi (5.14 +/- 1.08 micrograms/ml) than the values in patients with Lactobacillus sp. (pH < 4.5). Further, the intravaginal pH value was higher than 4.5 in all of these groups, which was higher compared with the one in the patients infected with Lactobacillus sp. (4.04 +/- 0.04).
在95例阴道和宫颈分泌物异常的患者（49例孕妇和46例非孕妇）中，研究了阴道内菌群与阴道内粒细胞弹性蛋白酶（弹性蛋白酶）及pH值之间的关系。结果如下。1）阴道分泌物中革兰氏阳性菌检出率较高（87/144，60.4%），主要为乳杆菌属（67/142，46.5%）。其次是厌氧菌（26/144，18.1%）和真菌（26/144，18.1%）。2）宫颈炎或阴道炎患者的弹性蛋白酶值（6.65 - 6.69微克/毫升）高于宫颈糜烂患者，阴道pH值不低于5.0的患者弹性蛋白酶值（6.44±1.40微克/毫升）显著高于pH值为4.5或更低的患者。3）关于检测到的细菌与弹性蛋白酶值之间的关系，厌氧菌（6.58±1.40微克/毫升）、革兰氏阴性菌（6.01±3.61微克/毫升）、革兰氏阳性菌（5.02±0.94微克/毫升）和真菌（5.14±1.08微克/毫升）感染患者的弹性蛋白酶值高于乳杆菌属感染患者（pH<4.5）。此外，所有这些组的阴道pH值均高于4.5，高于乳杆菌属感染患者（4.04±0.04）。
