Bachelot Anne, Lombardo Francesca, Baudin Eric, Bidart Jean-Michel, Schlumberger Martin
Department of Nuclear Medicine and Endocrine Tumors, Institut Gustave-Roussy, Villejuif, France.
Biochimie. 2002 Jan;84(1):61-6. doi: 10.1016/s0300-9084(01)01364-5.
Medullary thyroid carcinoma (MTC) arises from parafollicular or C cells of the thyroid that produce calcitonin. It accounts for 5-10% of all thyroid cancers. Hereditary MTC represents 20-30% of all MTCs. It can be transmitted with an autosomal dominant pattern, either as a single entity, familial MTC, or it can arise as part of a multiple endocrine neoplasia (MEN) syndrome type 2A or 2B. The identification of hereditary MTC has been facilitated in recent years by the direct analysis of the ret proto-oncogene.
甲状腺髓样癌（MTC）起源于甲状腺的滤泡旁细胞或C细胞，这些细胞会产生降钙素。它占所有甲状腺癌的5%-10%。遗传性MTC占所有MTC的20%-30%。它可以通过常染色体显性模式遗传，既可以作为单一实体，即家族性MTC，也可以作为2A型或2B型多发性内分泌肿瘤（MEN）综合征的一部分出现。近年来，通过对原癌基因ret的直接分析，有助于遗传性MTC的识别。
