Dominguez F, Pellicer A, Simón C
Fundación Instituto Valenciano de Infertilidad para el Estudio de la Reproducción Humana, Guardia Civil 23, 46020 Valencia, Spain.
Mol Cell Endocrinol. 2002 Jan 25;186(2):175-81. doi: 10.1016/s0303-7207(01)00659-1.
We know that the implantation process requires a functionally normal embryo at the blastocyst stage and a receptive endometrium, but also a communication link between them is needed. This paracrine dialogue between the embryo, endometrium and the corpus luteum are known to occur in ruminants and primates, more specifically endometrial-embryonic interactions have been reported in rodents and primates but not in humans. This process is a highly regulated mechanism and many molecules take part in this cross-talk. Here, we present updated information in humans on the embryonic regulation of endometrial epithelial molecules such as chemokines, adhesion and anti-adhesion molecules, and leptin during the apposition and adhesion phases of human implantation.
我们知道，着床过程需要处于囊胚期功能正常的胚胎和具有接受性的子宫内膜，而且它们之间还需要有一个通讯联系。已知反刍动物和灵长类动物胚胎、子宫内膜和黄体之间会发生这种旁分泌对话，更具体地说，啮齿动物和灵长类动物中已报道了子宫内膜与胚胎的相互作用，但人类中尚未见报道。这个过程是一种高度调控的机制，许多分子参与了这种相互作用。在此，我们提供关于人类着床附着和黏附阶段子宫内膜上皮分子（如趋化因子、黏附分子和抗黏附分子以及瘦素）的胚胎调控的最新信息。
