PGC7的鉴定，一种在植入前胚胎和生殖细胞中特异性表达的新基因。
Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells.
作者信息
Sato Masatake, Kimura Tohru, Kurokawa Ken, Fujita Yukiko, Abe Koichiro, Masuhara Masaaki, Yasunaga Teruo, Ryo Akihide, Yamamoto Mikio, Nakano Toru
机构信息
Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka Suita 565-0871, Japan.
出版信息
Mech Dev. 2002 Apr;113(1):91-4. doi: 10.1016/s0925-4773(02)00002-3.
The gene expression patterns of primordial germ cells (PGCs) and embryonic stem cells were analyzed by a modified serial analysis of gene expression. During the process, we cloned a novel gene, PGC7, which was preferentially expressed in PGCs. Immunohistochemical analysis revealed that PGC7 was specifically expressed in early pre-implantation embryos, PGCs and oocytes. These results suggest that PGC7 might play an important role in the development of PGCs and oocytes.
通过改进的基因表达序列分析方法，对原始生殖细胞（PGCs）和胚胎干细胞的基因表达模式进行了分析。在此过程中，我们克隆了一个新基因PGC7，该基因在原始生殖细胞中优先表达。免疫组织化学分析显示，PGC7在植入前早期胚胎、原始生殖细胞和卵母细胞中特异性表达。这些结果表明，PGC7可能在原始生殖细胞和卵母细胞的发育中发挥重要作用。
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