无模型连锁分析中多态性遗传标记的连锁信息含量值

The linkage information content value of polymorphism genetic markers in model-free linkage analysis.

作者信息

Guo Xiuqing, Olson Jane M, Elston Robert C, Niu Tianhua

机构信息

Division of Medical Genetics, Department of Medicine and Pediatrics, Spielberg Pediatrics Research Center, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif. 90048, USA.

出版信息

Hum Hered. 2002;53(1):45-8. doi: 10.1159/000048604.

DOI:10.1159/000048604

PMID:11901271

Abstract

Guo and Elston [Hum Hered 1999;49:112-118] developed a linkage information content (LIC) value to measure the informativeness of a marker for identity-by-descent (IBD) sharing status of relative pairs. LIC values were derived for five types of relative pairs: full sib, half sib, grandparent-grandchild, first cousin and avuncular. In this paper, we give corrected LIC values for full sib, grandparent-grandchild, first cousin and avuncular pairs, and indicate the availability of a computer program to calculate them.

摘要

郭和埃尔斯顿[《人类遗传学》1999年；49:112 - 118]开发了一种连锁信息含量（LIC）值，用于衡量一个标记对于亲属对按血缘相同（IBD）共享状态的信息量。得出了五种亲属对类型的LIC值：全同胞、半同胞、祖孙、一级表亲和叔侄。在本文中，我们给出了全同胞、祖孙、一级表亲和叔侄对的校正LIC值，并指出了一个用于计算它们的计算机程序的可用性。