Bacon G E, Larson R M, Spencer M L, Kelch R P
Am J Dis Child. 1975 Sep;129(9):1042-4.
An intravenous metyrapone tartrate test was performed on 26 children to assess growth hormone (GH) reserve and pituitary-adrenal axis. Results were compared to the response evoked by an estrogen-primed arginine-insulin tolerance test (ATT/ITT). Administration of metyrapone intravenously proved to be a reliable means of evaluating pituitary-adrenal function. However, a normal serum GH concentration (greater than or equal to 7 ng/ml) during the test occurred in only nine of 18 children who had an adequate response to the ATT/ITT, and in three of these, the peak GH level occurred at the start of the infusion. Therefore, this procedure does not appear to be a satisfactory test for GH reserve in children. Further, the discrepancy between time of the peak serum concentrations of compound S and GH following intravenous administration of metyrapone does not support the contention that the rise of GH level during stress is secondary to release of adrenocorticotrophic hormone.
对26名儿童进行了静脉注射酒石酸美替拉酮试验，以评估生长激素（GH）储备和垂体-肾上腺轴。将结果与雌激素激发的精氨酸-胰岛素耐量试验（ATT/ITT）所诱发的反应进行比较。静脉注射美替拉酮被证明是评估垂体-肾上腺功能的可靠方法。然而，在对ATT/ITT有充分反应的18名儿童中，只有9名在试验期间血清GH浓度正常（大于或等于7 ng/ml），其中3名儿童的GH峰值出现在输液开始时。因此，该方法似乎不是评估儿童GH储备的令人满意的试验。此外，静脉注射美替拉酮后化合物S和GH血清浓度峰值出现时间的差异并不支持应激期间GH水平升高继发于促肾上腺皮质激素释放的观点。
