Fung E B, Barden E M, Kawchak D A, Zemel B S, Ohene-Frempong K, Stallings V A
The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, 19104, USA.
J Pediatr Hematol Oncol. 2001 Dec;23(9):604-8. doi: 10.1097/00043426-200112000-00010.
Effects of hydroxyurea therapy on resting energy expenditure (REE) in children with sickle cell disease have not been evaluated. Eight children with sickle cell disease were examined before hydroxyurea therapy and again 6.9 +/- 3.5 months after hydroxyurea initiation. Resting energy expenditure, dietary intake, and growth were assessed. In six children, baseline REE was elevated, and REE decreased an average of 17% with hydroxyurea. This was associated with a significant increase in fetal hemoglobin. These pilot data suggest that hydroxyurea may curtail the hypermetabolic state observed in children with sickle cell disease and may offer a clinically important secondary benefit.
羟基脲疗法对镰状细胞病患儿静息能量消耗（REE）的影响尚未得到评估。对8名镰状细胞病患儿在接受羟基脲治疗前及开始治疗6.9±3.5个月后再次进行检查。评估了静息能量消耗、饮食摄入和生长情况。6名患儿的基线REE升高，使用羟基脲后REE平均下降了17%。这与胎儿血红蛋白的显著增加有关。这些初步数据表明，羟基脲可能会减轻镰状细胞病患儿中观察到的高代谢状态，并可能带来临床上重要的次要益处。
